Symptomatic sinus bradycardia due to electrolyte imbalances in syndrome of inappropriate antidiuretic hormone (SIADH) related covid-19: a case report

Amir M., Renata A., Ratana L.T.

Departement of Cardiology and Vascular Medicine, Hasanuddin University, Makassar, Indonesia; Dr. Wahidin Sudirohusodo National General Hospital, Makassar, Indonesia


Background: Coronavirus Disease-2019 (COVID-19) has been declared a global pandemic since March 11th, 2020. Despite emerging reports and literature covering a broad spectrum of COVID-19 clinical manifestations, facets of COVID-19 have not been fully elucidated. To the authors’ concern, sinus bradycardia as a manifestation of COVID-19-induced syndrome of inappropriate antidiuretic hormone (SIADH) has never been reported before. Case presentation: In this paper, we report a case of a 59-year-old male patient with confirmed COVID-19 initially presented with presyncope. Further investigations reveal sinus bradycardia related to COVID-19-induced SIADH. This case highlights the possibility of immuno-neuroendocrino-cardiovascular crosstalk resulting in an atypical manifestation of COVID-19: near syncope due to sinus bradycardia. Conclusions: Another possible cause of sinus bradycardia in COVID-19 is electrolyte imbalance due to COVID-19-related SIADH. © 2021, The Author(s).

COVID-19; Electrolyte imbalances; SIADH; Symptomatic sinus bradycardia


BMC Infectious Diseases

Publisher: BioMed Central Ltd

Volume 21, Issue 1, Art No 465, Page – , Page Count

Journal Link:

doi: 10.1186/s12879-021-06143-2

Issn: 14712334

Type: All Open Access, Gold, Green


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