Prevalence of plasma lipid disorders with an emphasis on LDL cholesterol in selected countries in the Asia-Pacific region

Lee Z.-V., Llanes E.J., Sukmawan R., Thongtang N., Ho H.Q.T., Barter P., on behalf of the Cardiovascular RISk Prevention (CRISP) in Asia Network

University Malaya Medical Centre, Kuala Lumpur, Malaysia; Division of Cardiovascular Medicine, University of the Philippines, Manila, Philippines; Department of Cardiology & Vascular Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Division of Endocrinology and Metabolism, Faculty of Medicine, Siriraj Hospital Mahidol University, Bangkok, Thailand; Heart Institute, Ho Chi Minh City, Viet Nam; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia


Abstract

Cardiovascular disease (CVD) is a major cause of mortality and morbidity within the Asia-Pacific region, with the prevalence of CVD risk factors such as plasma lipid disorders increasing in many Asian countries. As members of the Cardiovascular RISk Prevention (CRISP) in Asia network, the authors have focused on plasma lipid disorders in the six countries within which they have clinical experience: Indonesia, Malaysia, Philippines, Thailand, Vietnam, and Australia. Based on country-specific national surveys, the prevalence of abnormal levels of total cholesterol, low- and high-density lipoprotein cholesterol (LDL-C and HDL-C, respectively), and triglycerides (TG) are reported. An important caveat is that countries have used different thresholds to define plasma lipid disorders, making direct comparisons difficult. The prevalence of abnormal lipid levels was as follows: high total cholesterol (30.2–47.7%, thresholds: 190–213 mg/dL); high LDL-C (33.2–47.5%; thresholds: 130–135 mg/dL); low/abnormal HDL-C (22.9–72.0%; thresholds: 39–50 mg/dL); and high/abnormal TG (13.9–38.7%; thresholds: 150–177 mg/dL). Similarities and differences between country-specific guidelines for the management of plasma lipid disorders are highlighted. Based on the authors’ clinical experience, some of the possible reasons for suboptimal management of plasma lipid disorders in each country are described. Issues common to several countries include physician reluctance to prescribe high-dose and/or high-intensity statins and poor understanding of disease, treatments, and side effects among patients. Treatment costs and geographical constraints have also hampered disease management in Indonesia and the Philippines. Understanding the factors governing the prevalence of plasma lipid disorders helps enhance strategies to reduce the burden of CVD in the Asia-Pacific region. © 2021, The Author(s).

Asia-Pacific; Dyslipidemia; Guidelines; Plasma lipid disorders; Prevalence


Journal

Lipids in Health and Disease

Publisher: BioMed Central Ltd

Volume 20, Issue 1, Art No 33, Page – , Page Count


Journal Link: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104390743&doi=10.1186%2fs12944-021-01450-8&partnerID=40&md5=83b42d61490f8e1a6ee69953b6a780a5

doi: 10.1186/s12944-021-01450-8

Issn: 1476511X

Type: All Open Access, Gold, Green


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