Frozen vs. fresh cycles IVF outcomes: retrospective study from an Indonesian IVF centre

Permadi W., Bayuaji H., Tjandraprawira K.D., Tjahyadi D., Harlianto H., Achmad Y.M., Astarto N.W., Djuwantono T.

Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Bandung Fertility Center, Limijati Women and Children Hospital, Bandung, Indonesia


Objective: To compare the live birth rates (LBR) and neonatal outcomes of frozen cycle in vitro fertilization (IVF) with fresh cycle IVF in the Indonesian population. Results: This was retrospective study using secondary data of IVF patients at a private fertility centre. Study recruitment was between 3/8/2018 and 31/12/2019. Total sampling included all patients undergoing oocyte retrieval and embryo transfer within recruitment period. Patients undergoing fresh IVF cycles and frozen IVF cycles were compared. 351 patients were recruited: 68.1% (239/351) underwent fresh cycles and 31.9% (112/351) frozen cycles. AMH was significantly higher in frozen cycle group (p = 0.04). Ovulatory disorder was significantly higher in frozen cycle group (p = 0.001). Among patients aged ≤ 30, fresh cycle group had significantly higher LBR (p = 0.02). Among those with ovulatory disorder, LBR was significantly higher with frozen cycle. No significant LBR difference was noted with other infertility causes. When stratified according to pregnancy order, frozen cycle patients had significantly higher birth lengths (p = 0.03) but not length of gestation nor neonatal birthweights. There was no significant difference in the proportion of biochemical pregnancy resulting in LBR (p = 0.08). To conclude, frozen cycle provided higher LBR among patients with ovulatory disorder but fresh cycle was beneficial among patients aged ≤ 30. © 2021, The Author(s).

Embryo transfer; Fertilization in vitro; Frozen embryo transfer; Live birth


BMC Research Notes

Publisher: BioMed Central Ltd

Volume 14, Issue 1, Art No 177, Page – , Page Count

Journal Link:

doi: 10.1186/s13104-021-05585-w

Issn: 17560500

Type: All Open Access, Gold, Green


Bennett, L.R., Wiweko, B., Hinting, A., Adnyana, I.B., Pangestu, M., Indonesian infertility patients’ health seeking behaviour and patterns of access to biomedical infertility care: an interviewer administered survey conducted in three clinics (2012) Reprod Health, 9, p. 24; Blockeel, C., Drakopoulos, P., Santos-Ribeiro, S., Polyzos, N.P., Tournaye, H., A fresh look at the freeze-all protocol: a SWOT analysis (2016) Hum Reprod, 31 (3), pp. 491-497; Bourdon, M., Santulli, P., Maignien, C., The deferred embryo transfer strategy improves cumulative pregnancy rates in endometriosis-related infertility: a retrospective matched cohort study (2018) PLoS ONE, 13 (4), p. e0194800; Qiu, M., Tao, Y., Kuang, Y., Wang, Y., Effect of body mass index on pregnancy outcomes with the freeze-all strategy in women with polycystic ovarian syndrome (2019) Fertil Steril, 112 (6), pp. 1172-1179. , COI: 1:CAS:528:DC%2BC1MXisVKnsLnM; Bjercke, S., Tanbo, T., Dale, P.O., Mørkrid, L., Åbyholm, T., Human chorionic gonadotrophin concentrations in early pregnancy after in-vitro fertilization (1999) Hum Reprod, 14 (6), pp. 1642-1646. , COI: 1:CAS:528:DyaK1MXktFGhtLY%3D; Stormlund, S., Sopa, N., Zedeler, A., Freeze-all versus fresh blastocyst transfer strategy during in vitro fertilisation in women with regular menstrual cycles: multicentre randomised controlled trial (2020) BMJ, 370, p. m2519; Chen, Z.-J., Shi, Y., Sun, Y., Fresh versus frozen embryos for infertility in the polycystic ovary syndrome (2016) N Engl J Med, 375 (6), pp. 523-533; Mohamed, A.M., Chouliaras, S., Jones, C.J., Nardo, L.G., Live birth rate in fresh and frozen embryo transfer cycles in women with endometriosis (2011) Eur J Obstet Gynecol Reprod Biol, 156 (2), pp. 177-180; Feichtinger, M., Nordenhök, E., Olofsson, J.I., Hadziosmanovic, N., Rodriguez-Wallberg, K.A., Endometriosis and cumulative live birth rate after fresh and frozen IVF cycles with single embryo transfer in young women: no impact beyond reduced ovarian sensitivity—a case control study (2019) J Assist Reprod Genet, 36 (8), pp. 1649-1656; Zhu, Q., Chen, Q., Wang, L., Live birth rates in the first complete IVF cycle among 20 687 women using a freeze-all strategy (2018) Hum Reprod, 33 (5), pp. 924-929; Wang, A., Santistevan, A., Hunter Cohn, K., Freeze-only versus fresh embryo transfer in a multicenter matched cohort study: contribution of progesterone and maternal age to success rates (2017) Fertil Steril, 108 (2), pp. 254-261.e254. , COI: 1:CAS:528:DC%2BC2sXptFCls7Y%3D; Maheshwari, A., Raja, E.A., Bhattacharya, S., Obstetric and perinatal outcomes after either fresh or thawed frozen embryo transfer: an analysis of 112,432 singleton pregnancies recorded in the Human Fertilisation and Embryology Authority anonymized dataset (2016) Fertil Steril, 106 (7), pp. 1703-1708

Indexed by Scopus

Leave a Comment