Frozen vs. fresh cycles IVF outcomes: retrospective study from an Indonesian IVF centre

Permadi W., Bayuaji H., Tjandraprawira K.D., Tjahyadi D., Harlianto H., Achmad Y.M., Astarto N.W., Djuwantono T.

Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Bandung Fertility Center, Limijati Women and Children Hospital, Bandung, Indonesia


Abstract

Objective: To compare the live birth rates (LBR) and neonatal outcomes of frozen cycle in vitro fertilization (IVF) with fresh cycle IVF in the Indonesian population. Results: This was retrospective study using secondary data of IVF patients at a private fertility centre. Study recruitment was between 3/8/2018 and 31/12/2019. Total sampling included all patients undergoing oocyte retrieval and embryo transfer within recruitment period. Patients undergoing fresh IVF cycles and frozen IVF cycles were compared. 351 patients were recruited: 68.1% (239/351) underwent fresh cycles and 31.9% (112/351) frozen cycles. AMH was significantly higher in frozen cycle group (p = 0.04). Ovulatory disorder was significantly higher in frozen cycle group (p = 0.001). Among patients aged ≤ 30, fresh cycle group had significantly higher LBR (p = 0.02). Among those with ovulatory disorder, LBR was significantly higher with frozen cycle. No significant LBR difference was noted with other infertility causes. When stratified according to pregnancy order, frozen cycle patients had significantly higher birth lengths (p = 0.03) but not length of gestation nor neonatal birthweights. There was no significant difference in the proportion of biochemical pregnancy resulting in LBR (p = 0.08). To conclude, frozen cycle provided higher LBR among patients with ovulatory disorder but fresh cycle was beneficial among patients aged ≤ 30. © 2021, The Author(s).

Embryo transfer; Fertilization in vitro; Frozen embryo transfer; Live birth


Journal

BMC Research Notes

Publisher: BioMed Central Ltd

Volume 14, Issue 1, Art No 177, Page – , Page Count


Journal Link: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105606878&doi=10.1186%2fs13104-021-05585-w&partnerID=40&md5=8f16c492ef5ac09d200e73d104291ec4

doi: 10.1186/s13104-021-05585-w

Issn: 17560500

Type: All Open Access, Gold, Green


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