Chemical compounds and pharmacological activities of mangosteen (Garcinia mangostana l.)-updated review

Rizaldy D., Hartati R., Nadhifa T., Fidrianny I.

Department of Pharmaceutical Biology, School of Pharmacy, Bandung Institute of Technology, Bandung, Indonesia


Abstract

Mangosteen (Garcinia mangostana L.) is a tropical fruit belonging to Guttiferae (syn. Clusiaceae) family. Research on mangosteen has been widely conducted. Also, numerous in vitro and in vivo studies related to mangosteen have been published, indicating its significance and potential usefulness in the research field. This review was constructed by collecting and analyzing more than 50 research articles to explore the phytochemical contents and the medicinal benefits of mangosteen. A significant level of xanthones greatly contributes to the extensive pharmacological activities of mangosteen. Apart from xanthones, mangosteen also contained benzophenones, flavonoids, and anthocyanins. Mangosteen had a wide range of pharmacological effects, including antioxidant, anti-acne, anti-aging, anti-hyperpigmentation, antibacterial, antidiabetic, anti-obesity, anti-inflammatory, antimalarial, antiparasitic, and antitumor. Additionally, mangosteen has shown an advantageous activity toward pathological conditions such as Alzheimer’s, bipolar disorder, schizophrenia, neuropathic pain, and pulmonary fibrosis. This literature review indicated that xanthone in mangosteen had potential and promising to be developed as a drug candidate. More extensive explorations, especially in pharmacokinetic, pharmacodynamic, and xanthone targeting effects, are widely open to be carried out for future research. © 2021 by the authors.

Chemical compounds; Mangosteen; Pharmacological activities


Journal

Biointerface Research in Applied Chemistry

Publisher: AMG Transcend Association

Volume 12, Issue 2, Art No , Page 2503 – 2516, Page Count


Journal Link: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110105327&doi=10.33263%2fBRIAC122.25032516&partnerID=40&md5=8c60c743954f6aec040e0d1186564c6b

doi: 10.33263/BRIAC122.25032516

Issn: 20695837

Type:


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