A new havanensin-type limonoid from Chisocheton macrophyllus

Nurlelasari, Rahmayanti I., Salam S., Safari A., Harneti D., Maharani R., Hidayat A.T., Tanjung M., Retnowati R., Shiono Y., Supratman U.

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, 45363, Indonesia; Central Laboratory, Universitas Padjadjaran, Jatinangor, 45363, Indonesia; Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, 60286, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Malang, 65145, Indonesia; Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan


Abstract

A new havanensin-type limonoid, 16β-hydroxydysobinin (1), along with four known limonoids (2–5), have been isolated from the seeds of Chisocheton macrophyllus. The chemical structure of the new compound was determined by referencing spectroscopic data, and by comparison to those related spectra previously reported. Each compound was evaluated for their cytotoxic effects against Michigan Cancer Foundation-7 (MCF-7) breast cancer cells and display no significant activity. © 2021, The Author(s).

16β-hydroxydysobinin; Chisocheton macrophyllus; Limonoid; MCF-7; Meliaceae


Journal

Applied Biological Chemistry

Publisher: Springer Science and Business Media B.V.

Volume 64, Issue 1, Art No 35, Page – , Page Count


Journal Link: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103984255&doi=10.1186%2fs13765-021-00606-5&partnerID=40&md5=74eac9a2c056e7811469f1768c5d10b2

doi: 10.1186/s13765-021-00606-5

Issn: 24680834

Type: All Open Access, Gold


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